Review of Research Paper on Metastasis of Cancerous Tumors

Introduction Early diagnosis provides the best hope many have in beating cancer. Unfortunately, this is not the end of the fight for many cancer patients. Primary tumors may be successfully treated early, only to later discover they have metastasized to other areas of the body. The common medical definition of metastasis is: The spread of cancer from one part of the body to another. Tumors formed from cells that have spread are called â€Å"secondary tumors† and contain cells that are like those in the original (primary) tumor. This definition could be the reason why early treatment of a primary tumor is ineffective against metastatic tumor cells. As the definition suggests, the accepted model for the metastasis of tumor cells is through clonal evolution, where secondary tumors have similar genomes to the primary tumor. Recent studies suggest, however, that this may not be accurate. Significant divergence between primary and secondary tumors in renal cell metastases and breast metastases has been discovered in recent studies. An alternative model, one of a parallel evolution, would explain why therapies aimed at primary tumors are unsuccessful against metastatic cells. Further research on this alternative model could lead to therapies that not only target the properties of the primary tumor but also those of the secondary tumor and save many from the burden of fighting cancer again. Methods This study took 386 breast cancer patients and split them into two groups. M0, patients showing cells with no metastasis, and M1 patients, those that showed metastasis and performed a genomic analysis, or comparative genomic hybridization (CGH) of the Cytokeratin... ... tumor cells that could potentially disseminate, mutate, change, and grow into another tumor. More emphasis needs to be put on the development of disseminated cells because the changes in their growth cannot be reflected by the genomic data obtained from the primary tumor data; as a result, they can not be dealt with in the same manner. The main idea of this study is to underscore: "the need to validate potential cellular targets for adjuvant and systemic therapies on disseminated cancer cells directly"( Cancer Cell: July 2003). The paper that is being discussed is : Gray, J.W., Evidence emerges for early metastasis and parallel evolution of primary and metastatic tumors. Cancer Cell July 2003. Schmidt-Kittler, O. et al., From latent disseminated cells to overt metastasis: genetic analysis of systemic breast cancer progression. PNAS 100, 7734 (2003).

‘Miss Brill’ by Katherine Mansfield Essay

The short story ‘Miss Brill’ written in 1922 by Katherine Mansfield revolves around an elderly woman named Miss Brill. This particular short story is deeply influenced by Mansfield’s private life. Miss Brill is an unmarried, older English woman who lives by herself in a tiny apartment in France. She teaches English to students in France and reads the newspaper several times a week to an elderly man. The story is a reflection of Miss Brill’s inner conflicts, feelings of estrangement, loneliness and deep desire to be an important person. The old woman in the story wants very badly to belong to a family or a group. So every Sunday she goes to a seaside park, listens to the conversations of strangers and hears the band play. Her park visits help her in coping with her loneliness and provide her with much enjoyment. She sits on a special bench every week and listens to the conversations of others. While she listens to strangers she feels included and part of their lives. She experiences a sense of communion with the strangers in the park and imagines being a family member of the band. In this way, her rose colored glasses protect her from her lonely existence and empty life. Everything in the park is in great contrast to her actual life. The park for her is an alternate reality where she plays the part of an actress on a great stage. In reality, she is no longer important to anyone. However, in the park as an actress, her mere absence would cause great dismay to others. Her living conditions are gloomy and dark but the park that she visits is bright, sunny and filled with happiness. Her fur stole also becomes a dear pet when she visits the park. She attributes feelings and personality to the inanimate fur. She calls it her â€Å"little rogue!† and often strokes it affectionately. Another indicator of skewed reality is the fact that Miss Brill forgets that she herself is an old, odd, silent woman who had just come out of a dark room. She puts other elder people who also visit the park every Sunday in this category but not herself. By using these defenses she feels included, important and connected to other people around her. She fools herself into believing that she has a deep purpose in life. She has unintentionally set herself up to be hurt by reality. On one particular Sunday all her illusions are shattered. She is forced to understand her self-deception.   While looking at strangers, she sees an elderly woman with a fur hat. Miss Brill can identify with this other elderly woman. She sees the other woman being met by a gentleman. Like her lonely self, the other woman is also quite excited by new company.   The man pays no attention to her and instead rudely puffs into the other woman’s face. The man walks away but leaves the other woman humiliated. Miss Brill empathizes with the other woman and feels he has hurt both women equally. She quickly puts herself in her actress mode to avoid hurt and continues listening to others. She starts paying attention to the conversation of a young couple seated besides her.   The young man callously refers to her as â€Å"that stupid old thing†. He questions why the old lady comes to the park and why she strokes her stole. Instantaneously, her world of self deception is completely shattered. She finally understands that she is neither an actress on a stage nor an important part of this crowd. She has no choice but to return to her little apartment or her dark cupboard like room. This particular Sunday she does not stop by the bakers on her way back home. She feels no need to buy herself her usual slice of honey cake. She realizes that her coping mechanisms cannot help her cope with reality forever. At last, the young man’s rude remarks had woken her up from her happy dream into her nightmarish reality.

Explore the dramatic significance Essay

This scene takes place a few weeks after Marco and Rodolfo are first introduced into the play. The last scene has a climatic ending with recognition of apparent sexual attraction between Rodolfo and Catherine. In this scene, it appears that the two young characters have developed a liaison and intimacy, much to Eddie’s chagrin. This selected scene reveals to the audience not only the development of a romance between Rodolfo and Catherine but also the start of the deterioration of Eddie and Beatrice’s relationship as a result of Eddie’s affection for Catherine. The scene like many within the play, is introduced by Alfieri who pronounces: â€Å"Eddie Carbone never expected to have a destiny† (P22) thereby implying Eddie’s imminent downfall, similar to other protagonists found in Greek tragedies. However, as this is a modern tragedy, no one character is particularly corrupt. Indeed, they are just ordinary people. As confirmed in Alfieri’s speech as he asserts: â€Å"A man works, raises his family, goes bowling†¦ † (P22) Yet even inconsequential individuals can have extraordinary lives, and Miller encapsulates this in the play through the perceptive Chorus of Alfieri. Marco and Rodolfo who arrived at the Carbone household a few weeks prior to events occurring in this scene, are beginning to sense Eddie’s distress. During this introductory meeting Eddie generates a disliking for Rodolfo, which the audience realize, as a result of the magnetism between his niece and Rodolfo. He begins to only address Marco deliberately excluding Rodolfo from his conversation. Towards the end of this scene, Rodolfo and Catherine begin openly flirting, and in the background Eddie is seen with â€Å"his face puffed with trouble,†(P22) illustrating to the audience his future anxieties and jealousy in the play. Alfieri opens the scene, acting similarly to the chorus in a Greek tragedy. He comments upon the action whilst also instilling ideas into the audience’s mind. Being a lawyer, the audience regard him as a good judge of character. This is illustrated when he ends his speech with, â€Å"Now, as the weeks passed, there was a future, there was a trouble that would not go away. â€Å"(P22) Hence the audience will be awaiting the scene, hoping to find out what more danger lies ahead for this disillusioned protagonist, Eddie Carbone. Being the Chorus, Alfieri never leaves the stage, the lights dim or come up at his desk but he remains as judge over Eddie’s actions. The only other characters on the stage are Eddie and Beatrice. At the start of the scene, Eddie is standing at the doorway of the house anxiously waiting for Catherine and Rodolfo to return home from the cinema. Beatrice enters from the street, she is about to enter the house when Eddie talks to her. Miller gives many stage directions at this point as he knows exactly how he wants the scene to play out. The tension in which this scene begins is indicative of what is about to happen. Miller employs Eddie, his tragic hero, in this scene. It becomes obvious as to what his fatal flaw is. The role of Eddie is directed to be aggressive in order to attempt to conceal his inner anguish. Eddie â€Å"looks away† from Beatrice several times during their encounter, suggesting that he is ashamed of his feelings and obsession. His actions also reflect his growing disinterest in Beatrice, his wife, which mixed with his expanding interest in their niece creates a highly complex and dangerous situation. Nonetheless, Beatrice acts as the good wife and â€Å"smiles† at him when she catches sight of him. Despite this, Eddie looks away which emphasizes tension as it illuminates that there is some unease on Eddie’s part. Beatrice then continues to try and keep the mood light whilst avoiding the words she would have liked to say about her husband’s inappropriate affections. Miller directs her role to be more assertive causing the tension to rise further as what she is saying puts Eddie in a increasingly awkward state. Miller’s range of language devices in the play effectively bring out both character and theme. Alfieri’s language includes the dialogue spoken by an educated man critically aware of the tragic situation that is unraveling: â€Å"Who can ever know what will be discovered? † Miller thereby creates curiosity in the audience through his use of interrogative as well as a sympathetic response to Eddie who by now no longer can control his emotions. That said, Beatrice and Eddie speak in the simple dialect of the Italian American community, â€Å"You crazy or sump’m? † Beatrice (P23). Suggesting that she does not have the capacity to articulate her worries. In this section, Eddie refers to Rodolfo as ‘That’ several times; the absence of pronouns suggest that Eddie does not see Rodolfo as a person, more of a problem or obstacle which he has to overcome to save Catherine. The derogative language also implies sub-human, a reference to an animal, ergo proving that he deems Rodolfo as inadequate and displaying his hostility towards him. Ultimately, Eddie craves to convince Beatrice that Rodolfo is homosexual through facts like Rodolfo blonde and that male singers lack masculinity. Beatrice recognizes Eddie’s suggestions. In the stage directions, Miller writes that, ‘She realizes †¦ a campaign solidified in him. ‘ and as a result she takes a stand telling him, â€Å"Ain’t gonna start nothin’ here. † (P23) Her anger behind Eddie’s innuendos come from her realization of his jealousy as well as the fact that Eddie has not, as was case in 1940’s, fully understood what it is to be homosexual.

The role of human resources management in employee motivation The WritePass Journal

The role of human resources management in employee motivation Introduction The role of human resources management in employee motivation IntroductionHow Human Resource Management plays an important rule in employee motivation?Employee motivationLeadership Skills and Leadership BehaviorsEffective Leadership BehaviorsCONCLUSIONThe PurposeThe MethodThe ImplementationThe Considerations – Communication SkillsThe Considerations – Listening SkillsReferencesRelated Introduction Human resource management (HRM) is a strategic and coherent approach for the management of an organizations most precious assets the employees working there who individually and collectively contribute to the achievement of the objectives of the business. The term human resource management and human resources (HR) have strongly replaced the term personnel management as a description of the processes involved in managing people in organization. In very simple words, HRM means employing people and developing their capacities and utilizing and maintaining and compensating their services in tune with the job and organizational needs and requirements. Human resources management includes several processes and stages. Both Together they are supposed to reach the above mentioned targets and goal. These processes can be carried on in an HR department, but some of the tasks and jobs can also be outsourced or performed by line managers or the other departments. When effectively performed they provide significant outstanding economic benefits to the organization. Human resources management presses and stages are: Workforce planning Recruitment (sometimes separated into attraction and selection) Induction, Orientation and Onboarding Skills management Training and development Personnel administration Compensation in wage or salary Time management Travel management (sometimes assigned to accounting rather than HRM) Payroll (sometimes assigned to accounting rather than HRM) Employee benefits administration Personnel cost planning Performance appraisal Labor relations How Human Resource Management plays an important rule in employee motivation? Employee motivation To be able to have a good effective workforce and to encourage and motivate them to give and do their best while at work it requires attention to all of the financial and also psychological and even physiological rewards offered by the organization as a non stop continuous exercise. The Basic financial rewards and conditions of service example working hours per week are determined externally by the national bargaining or government minimum wage legislation departments in many occupations but as much as 50 per cent of the gross pay of the manual workers is often the result of local negotiations and details example which particular hours shall be worked of conditions of service are often more important than the basics. Hence there is scope for financial and other motivations to be used at all levels. As the staffing needs will vary with the productivity of the employees (and the industrial peace achieved) so good personnel policies are desirable. The latter can depend upon other factors (like environment, welfare, workforce benefits and so on but unless the pay rat is accepted as a fair and just there will be no good motivation. Also the technicalities of payment and other systems may be the concern of others; the outcome of them is a subject of a great concern to human resource management. Increasingly the influence of behavioral science discoveries is becoming important not merely because of the widely acknowledged limitations of money as a motivation factor, but because of the changing mix and the nature of tasks example more service and professional jobs and far fewer unskilled and repetitive production jobs. So the situation demands a better educated mobile and multi-skilled workforce is much more likely to be influenced by other things like job satisfaction, involvement, participation and so on. than the economically dependent workforce of the past. Human resource management are suppose to be acting as a source of information about and a source of inspiration for the application of the findings of behavioral science. It may be a matter of paying the attention of the senior managers to what is being achieved elsewhere and the gradual education of middle managers to new points of view on job design, work organization and worker autonomy. Leadership Skills and Leadership Behaviors A good leader must develop their leadership skills and work to demonstrate and improve many positive leadership behaviors and to eliminate all of the negative leadership behaviors. These positive behaviors must be demonstrated at all times in all situations so that it is simply how the good leader works on. Leadership development is a continuous nonstop process of personal development. Effective Leadership Behaviors So many Different leadership studies highlight the importance of effective leadership behaviors, whether they are based on under-graduates or commercial managers at every level in an organization. In short words, there are commonalities that emerge from this research time and again, which characterize positive behaviors and negative behaviors. Whilst there may be significant differences at the detailed level there seems to be a broad consensus of positive leadership behaviors: Effective project planning and management Conducts regular, effective meetings to set objectives, allocate tasks and review performance Identifying the right person for the right role Appropriate delegation of responsibility whilst retaining accountability Consults and includes others in decision-making Shows an interest in others and responding to their needs whether that is for more information, guidance, support, personal development, positive feedback or reward and recognition Takes ownership and shows commitment for solving problems or difficult/sensitive issues Direct, clear, open style of communication Considers impact before action Leads by example, showing a contagious passion and enthusiasm, engaging and motivating other CONCLUSION In conclusion Leadership behavior can help motivate team members of the workforce for the better or worse. Subordinates look to leadership for guidance, support and direction. If leadership’s behavior does not match their words of encouragement, morale and motivation can be lost. Leadership’s behavior is just as important as the words used to inspire subordinates. Motivation is the force behind what drives people to work more efficiently and go the extra mile. The Purpose The purpose and the reason of motivation are to inspire the workforce to take positive actions. What a leader does can motivate the workforce to respond with a desire to work harder and more efficiently. For example, if the leader is appreciative and demonstrates it with the use of words, gifts and rewards, her followers will be more motivated to remain dedicated to their work on her behalf. Leadership behavior that wins the trust from followers promotes a positive corporate culture and spurs people toward being motivated. The Method In order To be able to motivate employees the leadership behavior must expose a need in the followers and a proper solution for that need. For example if the leaders recognized that his or her followers are using outdated equipments that’s frustrating to work with and replace it the followers will feel more respected and more taken care of. In turn, this makes the loyalty and dedications to the leader. The leaders who use his behavior to respond to his followers needs will result in motivated followers. The Implementation Any kind of a leader needs to perform some actions and personal behavior to inspire his workforce to motivation. This can be done by participating in a democratic leadership style where followers are included in decision making processes by encouraging comments, asking the employees some questions and taking the their suggestions and ideas with seriously and consideration. Rewarding subordinates is another behavior that leaders use to produce motivated employees. The Considerations – Communication Skills The way a leader communicates has the ability to empower or discourage the workforce. Communication is the process of using spoken words (verbal) and nonverbal messages such as body language, facial expressions and tone of the voice to receive and send messages so The more effective a leader’s communications are, the more his workforce are provided direction, purposes and satisfaction. The Considerations – Listening Skills The leader who demonstrates an effective listening skill is able to send a strong message that he or she cares and is leading with the best interest of the team in mind. Listening skills include making mental actions, asking questions, recall the information back to the sender and responding the message. Effective listening also are able use nonverbal cues, such as body language and nodding the head, to let the other person know she is listening. References Armstrong, Michael (2006). A Handbook of Human Resource Management Practice (10th ed.). London: Kogan Page. ISBN  0-7494-4631-5. OCLC  62282248. personnel management. The Columbia Encyclopedia (Sixth Edition Ed.). Columbia University Press. 2005. bartleby.com/65/x-/X-personne.html. Retrieved 2007-10-17. personnel management see industrial management. Encyclopà ¦dia Britannica (kl ed.). Personnel administration is also frequently called personnel management, industrial relations, employee relations. Encyclopà ¦dia Britannica. Towers, David. Human Resource Management essays. towers.fr/essays/hrm.html. Retrieved 2007-10-17. Golding, N. (2010) Strategic Human Resource Management in Beardwell, J. and Claydon, T. (2010) Human Resource Management A Contemporary Approach, FT Prentice Hall Storey, J. (2007) What is strategic HRM? in Storey, J. (2007) Human Resource Management: A Critical Text, Thompson Paauwe, J. (2009) HRM and Performance: Achievement, Methodological Issues and Prospects Journal of Management Studies, 46 (1) Pfeffer, J. (1994) Competitive advantage through people, Harvard Business School Press Becker, B. and Gerhart, B. (1996) The impact of human resource management on organizational performance Academy of Management Journal 39 (4) 779-801   Kochan, T. and Barocci, T. (1985) Human Resource Management and Industrial Relations, Little Brown

Atlantic Puffin essays

Atlantic Puffin essays The Atlantic Puffin is member of the Alcidae Family. These birds can be found abundantly, estimated 14 million, in the North Atlantic ocean. They can be found on both sides of the Atlantic ocean, but a much larger population is found in Greenland, Iceland, and Norway. They only come ashore to breed and raise a chick. Puffins range in size from 11.5-13.5 inches in length, and their wingspan 21-24 inches. Their weight is usually no more than 490.5 grams. They have been given nicknames like sea parrot and clowns of the sea because of their multi-colored bills. Atlantic puffins were once used by humans for their feathers, which were used in ladies hats. Today they are a common food item in Iceland.( ) Something else that makes these birds so unique is their eyes. They are set deeply in the skull with round full cheeks. Around the eye there is crimson ring and above it a small triangular blue, horny plate and below it a bar similar in color. However it is only during breeding season that the Atlantic Puffin sports its colorful red, yellow, and blue beak. Once nesting season is over the color disappears. During the winter months both adult and juvenile have a dirty gray face, usually the juveniles is even darker. From September through February these birds can be located from the North Atlantic into the Mediterranean Sea. While at sea they can swim easily, riding the waves even in the roughest weather. Puffins feed on small fish mollusks, and crustaceans. They are able to catch these animals from wither the air or water. They dive down and swallow the animals underwater. Towards the end of February and early March the start to arrive at their nesting grounds . They usually gather just offshore in rafts. As the season advances , and more time is spent on land, the birds bond with eat other, cooing and nibbling. Both male and ...

Pope Leo III - Charlemagnes Pope - Pope Saint Leo III

Pope Leo III - Charlemagne's Pope - Pope Saint Leo III Pope Leo III was also known as: Charlemagnes Pope Pope Leo III is noted for: crowning Charlemagne Emperor and establishing the precedent that only the pope could confer the imperial crown. Leo was also physically attacked in the streets of Rome by supporters of his predeccessor. Occupation Role in Society: PopeSaint Places of Residence and Influence: Italy Important Dates: Elected pope: Dec. 26, 795Attacked: April 25, 799Died: June 12, 816 About Pope Leo III: Rather than keeping the papacy independent of secular authorities, Leo deliberately took steps to ally with Charlemagne and his growing empire. Attacked in the streets of Rome by supporters of his predecessors nephew, Leo sought the aid of Charlemagne and eventually crowned him emperor, establishing an important precedent. As pope, Leo was adept in diplomacy and managed to keep his Carolingian allies from exerting any real influence on matters of doctrine. He died in 816. For more about Leo, visit your Guides Concise Biography of Pope Leo III. More Leo III Resources: Concise Biography of Pope Leo IIIImage of Leo crowning Charlemagne Leo III on the Web Pope St. Leo IIIFairly substantial bio by Horace K. Mann at the Catholic Encyclopedia.Pope Saint Leo IIIConcise collection of useful data, heavily hyperlinked, at the Patron Saints Index. Leo III in Print The links below will take you to a site where you can compare prices at booksellers across the web. More in-depth info about the book may be found by clicking on to the books page at one of the online merchants. by Richard P. McBrienby P. G. Maxwell-Stuart Chronological Index Geographical Index Index by Profession, Achievement, or Role in Society

Wanting to become an auditor Essay Example | Topics and Well Written Essays - 500 words

Wanting to become an auditor - Essay Example The spirit of the law is demonstrated by examining the legitimate goals of a company, which provide it with ethical direction and by examining the duties of the accounting professionals who are accountable to the company as well as the general public. These professional responsibilities are determined by their legitimate economic functions. The major responsibilities of the external auditor are first, to evaluate financial statements and ensure that such statements reflect the financial facts of a company and second, to closely monitor the financial markets and query irregular practices that would obfuscate the facts. To achieve these objectives the auditor has to resort to professional skepticism.1 The competence of an accountant is dependant to a very large extent on the skill possessed in handling numbers. Since, this skill can be used to misrepresent and distort the true position, it has to be concluded that in the absence of morality a good accountant is not a moral or ethical accountant. The auditor’s duty is to ensure that accounting or the language of business is properly utilized so that the financial data is interpreted correctly. Moreover, the function of the independent auditor is that of a watchdog and the auditor has to ensure that the companys assessments are reasonable and not at variance with the reality. Further, these assessments are to be made on the basis of a consistent policy, which does not change over the years. It is the duty of the external auditor to certify that the financial statement of a company fairly represents its financial position as such certifications are essential requirements for an efficient financial market. The spirit behind these functions has been seriously violated in recent years. Blind insistence on compliance with the principles, practices and conventions has relegated to the background the all important requirement that financial statements should provide clear and unambiguous details of the